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How Effective Is NeuroStar® TMS Therapy?

Safe. Non-invasive. Backed by Science.

For adults with Major Depressive Disorder (MDD) who haven’t found relief with medication, NeuroStar TMS Therapy offers a powerful alternative.

In clinical trials, it has shown lasting results — even for patients with significant treatment resistance.

For many of our patients, TMS has been the turning point — restoring energy, hope, and connection.

Clinical Outcomes at a Glance

1 in 2 patients had a significant reduction in symptoms
1 in 3 achieved complete remission
Patients were 4x more likely to remit than those receiving a sham treatment

These results come from a randomized, controlled trial funded by the National Institute of Mental Health, involving 307 patients over 4–6 weeks of treatment.

Treatment-Resistant Depression: TMS Still Works

TMS was effective for patients with:

Low treatment resistance (after 1 failed antidepressant)
High treatment resistance (after 2–14 failed antidepressants)

No matter where you are in your treatment journey, there’s hope.

Long-Term Relief That Lasts

NeuroStar is the only TMS system with results proven to last 12 months after treatment.

2 out of 3 patients who improved stayed better after one year
Only 1 in 3 needed occasional maintenance treatments
Many patients continued to feel better while on or off medication

Neurostar Efficacy

Clinical trials have demonstrated the effectiveness of NeuroStar® TMS Therapy in treating patients who have not benefited from prior antidepressant medication. NeuroStar TMS Therapy was studied in adult patients suffering from Major Depressive Disorder, all of whom had not received satisfactory improvement with previous treatments.

An Effective and Durable Option for Treating Major Depressive Disorder

In an independent, randomized, controlled trial funded by the National Institute of Mental Health, 307 patients were treated with the NeuroStar TMS System for 4 to 6 weeks, similar to a real clinical context.

Patients were divided into two groups:

A) Low Treatment Resistance: Patients who have failed to improve their depression symptoms after a single antidepressant treatment of adequate dose and duration.

B) High Treatment Resistance: Patients who have failed to improve their depression symptoms after multiple (2-14) antidepressant treatments of adequate dose and duration.

At the end of their treatments, patients who had received NeuroStar TMS Therapy were four times more likely to achieve remission compared to patients receiving a sham treatment. 1 in 2 patients experienced significant improvement in their depression symptoms and 1 in 3 experienced complete remission. Patients treated with the NeuroStar TMS System also experienced significant improvement in anxiety and physical symptoms (such as appetite changes, aches and pains, and lack of energy) associated with depression.

Durability of TMS Treatments

NeuroStar TMS is the only TMS system with the durability of its effects established over 12 months.

In a trial with physician-directed standard of care, meaning Neurostar TMS Therapy could be used in conjunction with antidepressants as needed, patients who had received treatment then reported their symptom levels at 3, 6, 9 and 12 months to determine the durability of their treatments. By the end of the 12-month period, 2 out of 3 patients who had either responded or completely remitted after TMS treatment remained at the symptom levels they reported at the end of the treatment phase

After the end of the treatment period, only 1 in 3 patients needed to come back for maintenance TMS sessions, or ‘reintroduction’ during this 12-month period.

TMS+YOU is an online community and national patient advocacy site for TMS Therapy. Those considering Transcranial Magnetic Stimulation can connect with patients who have had the treatment to answer questions, share insights, and get the latest information.